Discussions on liquid bismuth target use as an alternative for astatine-211 production

Discussions on liquid bismuth target use as an alternative for astatine-211 production

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Astatine-211 is an alpha emitter that has been identified as a good candidate for targeted alpha therapy.There is an increasing demand on this radionuclide.Very intense beam from linac being put in operation nowadays CD Wire Harness could be used to meet this demand.This document presents the design exploration of concepts of liquid bismuth targets dedicated to astatine-211 production.

Three concepts are presented and analyzed: a Hydration capsule, a fluid loop and a windowless fluid loop.Structural and thermal sizing were performed using mechanical Finite Element models (ANSYS Workbench) and Computational Fluid Dynamic models (FLUENT).Production rates were assessed accordingly.Feasibility and expected performances are discussed in conclusion.